成果归属作者：

郭华明

成果归属机构：

水资源与环境学院

作者：

Zhao, Yi ; Xu, Rui ; Cox, Siobhan F. ; Qiao, Min ; Guo, Huaming

单位：

China Univ Geosci Beijing, State Key Lab Biogeol & Environm Geol, Beijing 100083, Peoples R China;China Univ Geosci Beijing, Key Lab Groundwater Conservat MWR, Beijing 100083, Peoples R China;China Univ Geosci Beijing, Sch Water Resources & Environm, Beijing 100083, Peoples R China;Queens Univ Belfast, Sch Nat & Built Environm, David Keir Bldg, Stranmillis Rd, Belfast BT9 6AX, North Ireland;Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China

关键词：

MOBILE GENETIC ELEMENTS; COSELECTION; COOCCURRENCE; AGENTS

摘要：

Metals are increasingly important risk factors for the evolution of antibiotic resistance in environments.The rapid development of antibiotic resistance is occurring at a global scale. We therefore stride into the post-antibiotic era and have to battle antibiotic resistance in the Anthropocene. Metals are widely used and their pollution is widespread worldwide. More importantly, metal-induced co-selection greatly expands the environmental resistomes and increases the health risk of antibiotic resistance in environments. Here, we reviewed the metal-induced co-selection and their increasingly important roles in the development of antibiotic resistance. In particular, we highlight the metal-rich environments that maintain reservoirs for high-risk antibiotic resistance genes with horizontally transferable potentials. We also call for considerations and further investigations of other co-selective agents and the efficacy of metal-based interventions to better manage and combat the global antibiotic resistance crisis within the One Health framework.

基金：

National Natural Science Foundation of China [41825017, 42377392, 42107407]; Fundamental Research Funds for the Central Universities [265QZ2022006]

语种：

英文

DOI：

10.1007/s42832-024-0244-4

来源：

SOIL ECOLOGY LETTERS,2024(4):.

出版日期：

2024-12

提交日期：

2024-05-14

引用参考：

Zhao, Yi; Xu, Rui; Cox, Siobhan F.; Qiao, Min; Guo, Huaming. Metals are overlooked in the evolution of antibiotic resistance[J]. SOIL ECOLOGY LETTERS,2024(4):.